Efficacy of vitamin D supplementation on glycaemic control in type 2 diabetes: An updated systematic review and meta‐analysis of randomized controlled trials
Authors' conclusion
Vitamin D supplementation can significantly reduce serum FBG, HbA1c, HOMA-IR and fasting insulin levels in T2D patients; the effects were especially prominent when vitamin D was given in a short-term, high dosage to patients with a vitamin D deficiency, who were overweight, or had an HbA1c of 8% or higher at baseline. Our study suggests that vitamin D supplements can be recommended as complementary treatment for T2D patients.
Study context
- Population
- Subjects with T2D
- Participants
- 2,982 subjects39 RCTs
- Comparison
- Vitamin D supplementation vs control
- Outcome
- Glycaemic control: Fasting blood glucose (FBG), HbA1c, fasting insulin, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) (and serum 25(OH)D)
Pooled result
As reported in the abstract
Glycaemic control
Each group vs controlWMD (FBG), mmol/L (95% CI)
Vitamin D
−0.49(−0.69 to −0.28)
Each group vs controlWMD (HbA1c), % (95% CI)
Vitamin D
−0.30(−0.43 to −0.18)
Each group vs controlWMD (HOMA-IR) (95% CI)
Vitamin D
−0.39(−0.64 to −0.14)
Each group vs controlWMD (insulin), μIU/mL (95% CI)
Vitamin D
−1.31(−2.06 to −0.56)
Further pooled results
Subgroup analyses
- Effects on glycaemic control depend on dosage and duration of supplementation, baseline 25(OH)D levels and BMI
Original publication
Efficacy of vitamin D supplementation on glycaemic control in type 2 diabetes: An updated systematic review and meta‐analysis of randomized controlled trials. Diabetes Obes Metab. Published 2 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →