Association of a composite trait for anthropometrics, adiposity and energy expenditure with cardiometabolic diseases: An age‐stratified cohort and genetic risk score analysis
Authors' conclusion
The consistently observed weaker associations of the composite traits with cardiometabolic disease suggests the need for age-specific cardiometabolic disease prevention strategies.
Study context
- Population
- European ancestry participants from UK Biobank; mean age 58.0 years, 56% womenUK Biobank
- Participants
- 418,963 participants
- Comparison
- Composite body composition traits and incident T2D and coronary artery disease (CAD), by age
- Outcome
- Incident T2D and coronary artery disease (CAD)
Methodological detailsage-stratified, principal components analysis, multivariable-adjusted Cox regression, genome-wide association studies, 11 measures of adiposity, anthropometrics and energy expenditure reduced by principal components (PC) analyses, GWAS in half of cohort (N = 156,295); genetic risk score analyses in other half stratified by age of disease onset (N = 156,295)
- Age-stratified
- Principal components analysis
- Multivariable-adjusted Cox regression
- Genome-wide association studies
- 11 measures of adiposity, anthropometrics and energy expenditure reduced by PC analyses
- GWAS in half of cohort (N = 156,295); genetic risk score analyses in other half stratified by age of disease onset (N = 156,295)
Performance
As reported in the abstract
PC1 genetic risk score and CAD and T2D risk
CAD cases <50 years, OR per SD
0.91
95% CI 0.87, 0.94
T2D cases <50 years, OR per SD (0.72, 0.81)
0.76
Attenuation of CAD association with higher age, p-value
8.13E-4
Attenuation of T2D association with higher age, p-value
2.41E-6
Original publication
Association of a composite trait for anthropometrics, adiposity and energy expenditure with cardiometabolic diseases: An age‐stratified cohort and genetic risk score analysis. Diabetes Obes Metab. Published 2 October 2024. doi:10.
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