Differential and sex‐ and age‐specific risks of cardiometabolic diseases with unrelated metabolic syndrome dimensions
Authors' conclusion
MetS can be dissected into two distinct presentations characterized by differential sex- and age-associated cardiometabolic disease risk, confirming the loss of information using the dichotomous MetS.
Study context
- Population
- Unrelated European-ancestry UK Biobank participants (55% women)55% women
- Participants
- 153,073 participants
- Exposure
- PC1 vs PC2 dimensions of metabolic syndrome (MetS)
- Outcome
- Incident T2D, coronary artery disease (CAD) and (ischemic) stroke
Methodological detailsprincipal components analysis, multivariable-adjusted Cox proportional hazards models, stratified by sex and baseline age
- Principal components analysis
- Multivariable-adjusted Cox proportional hazards models
- Stratified by sex and baseline age
Main finding
As reported in the abstract
Incident cardiometabolic disease
| Group | HR for coronary artery disease (CAD) | HR for T2D |
|---|---|---|
| PC1 | 1.27 (95% CI 1.25-1.29) | 2.09 (95% CI 2.03-2.16) |
| PC2 | 1.06 (95% CI 1.03-1.08) | 1.39 (95% CI 1.34-1.44) |
HR for coronary artery disease (CAD)
PC11.27 (95% CI 1.25-1.29)
PC21.06 (95% CI 1.03-1.08)
HR for T2D
PC12.09 (95% CI 2.03-2.16)
PC21.39 (95% CI 1.34-1.44)
Observational data: associations, not effects.
Further findings
Sex- and age-specific associations
- p values for heterogeneity test among subgroups
- < 0.05
- Association of PC1 with T2D slightly higher for women than men
- HRs of PC1 with CAD and T2D attenuated with increasing age
Original publication
Differential and sex‐ and age‐specific risks of cardiometabolic diseases with unrelated metabolic syndrome dimensions. Obesity (Silver Spring). Published 30 May 2023. doi:10.
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