Associations of diabetes, prediabetes and diabetes duration with the risk of chronic obstructive pulmonary disease: A prospective UK Biobank study
Authors' conclusion
Our findings indicate that diabetes, prediabetes and a longer diabetes duration are associated with a higher risk of and worse survival for COPD. Future studies are warranted to determine the optimal way of diabetes control that might reduce COPD risk.
Study context
- Population
- Participants without chronic obstructive pulmonary disease (COPD) at baseline, UK Biobank12,595 incident COPD
- Participants
- 452,680 participants
- Exposure
- Prediabetes and diabetes vs reference group
- Outcome
- Incident COPD
- Follow-up
- Median 12.3 years
Methodological detailsUK Biobank, multivariable-adjusted Cox regression, restricted cubic splines
- UK Biobank
- Multivariable-adjusted Cox regression
- Restricted cubic splines
Main finding
As reported in the abstract
COPD risk
Each group vs referenceHazard ratio (95% CI)
Prediabetes18% higher risk
1.18(1.13–1.24)
Diabetes35% higher risk
1.35(1.24–1.47)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| COPD risk by diabetes durationDuration ≥7 yearsvs Duration <1 yearMultivariable-adjusted | 1.23 (1.05–1.44) | |
| COPD risk by diabetes durationDuration 3 to <7 yearsvs Duration <1 yearMultivariable-adjusted | 1.20 (1.04–1.39) | |
| COPD risk by diabetes durationDuration 1 to <3 yearsvs Duration <1 yearMultivariable-adjusted | 1.18 (1.01–1.37) | |
| Overall death among incident COPD patientsPrediabetesvs Reference9% higher risk | 1.09 (1.00–1.19) | |
| Overall death among incident COPD patientsDiabetesvs Reference21% higher risk | 1.21 (1.05–1.41) | |
| Overall death among incident COPD patientsDuration ≥7 yearsvs Duration <1 year46% higher risk | 1.46 (1.11–1.92) | |
| 0.512Hazard ratio (log scale) |
- Overall death among incident COPD patients: n = 12 595 incident COPD
COPD risk by diabetes duration
- Non-linear dose-response relationship between diabetes duration and COPD risk
Original publication
Associations of diabetes, prediabetes and diabetes duration with the risk of chronic obstructive pulmonary disease: A prospective UK Biobank study. Diabetes Obes Metab. Published 29 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →