Metabolic Syndrome and C-reactive Protein are Associated With a Reduced Myocardial Mechano-energetic Efficiency
Authors' conclusion
Nondiabetic and prediabetic individuals with metabolic syndrome exhibit increased stroke work and myocardial oxygen consumption, and an impaired MEEi, an established predictor of adverse cardiovascular events, and elevated hsCRP levels in combination with metabolic syndrome aggravate the myocardial MEEi impairment.
Study context
- Population
- Nondiabetic and prediabetic individuals; myocardial mechano-energetic efficiency (MEE) assessed by validated echocardiography-derived measure
- Participants
- 1,975 participants
- Exposure
- Metabolic syndrome vs no metabolic syndrome; High-sensitivity C-reactive protein (hsCRP) ≥3 vs <3 mg/L
- Outcome
- Myocardial mechano-energetic efficiency per gram of LV mass (MEEi)
Main finding
As reported in the abstract
Myocardial MEEi
- Metabolic syndrome: increased stroke work and myocardial oxygen consumption (rate pressure product) and reduced MEEi vs no metabolic syndrome, adjusted for age and sex
- MEEi progressively decreased with increasing number of metabolic syndrome components
- Metabolic syndrome and hsCRP independently contributed to reduced MEEi in multivariable regression
- hsCRP ≥3 mg/L associated with reduced MEEi both with and without metabolic syndrome
Observational data: associations, not effects.
Original publication
Metabolic Syndrome and C-reactive Protein are Associated With a Reduced Myocardial Mechano-energetic Efficiency. J Clin Endocrinol Metab. Published 26 May 2023. doi:10.
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