Vitamin K1 Intake and Incident Diabetes in the Danish Diet, Cancer, and Health Study
Main finding · Incident diabetesResult — go to the resultHazard ratio 0.69 95% CI 0.64–0.74Authors' conclusion
Higher intake of foods rich in vitamin K1 was associated with a lower risk of diabetes. If the associations observed are causal, our results indicate that more cases of diabetes would be prevented in subgroups at higher risk (men, smokers, participants with obesity, and those with low physical activity).
Study context
- Population
- Danish residents with no history of diabetes, Danish Diet, Cancer, and Health Study; median (IQR) age 56 (52–60) years at baseline6,700 diagnosed with diabetes
- Participants
- 54,787 residents
- Exposure
- Highest vs lowest vitamin K1 intake
- Outcome
- Incident diabetes
- Follow-up
- 20.8 (17.3-21.6) years
Methodological detailsmultivariable-adjusted Cox proportional-hazards models
- Multivariable-adjusted Cox proportional-hazards models
Main finding
As reported in the abstract
Hazard ratio
0.69
95% CI 0.64–0.74
Highest intakevs Lowest intake
HR 0.69 (95% CI 0.64–0.74)
- Vitamin K1 intake inversely and linearly associated with incident diabetes
- P < 0.0001
Observational data: associations, not effects.
Further findings
Incident diabetes by subgroup (sex, smoking, physical activity, BMI category)
- Inverse association present in all subgroups (men and women, ever and never smokers, low and high physical activity, normal to overweight and obese), with differences in absolute risk between subgroups
Original publication
Vitamin K1 Intake and Incident Diabetes in the Danish Diet, Cancer, and Health Study. J Clin Endocrinol Metab. Published 26 May 2023. doi:10.
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