Methyl Donor Nutrient Intake and Incidence of Type 2 Diabetes: Results From Three Large U.S. Cohorts
Authors' conclusion
The results of our study suggest that higher intake of vitamin B2 and B6, especially B2 from food sources, may be associated with a modestly lower type 2 diabetes risk.
Study context
- Population
- Women and men from the Nurses' Health Study (1984–2016), Nurses' Health Study 2 (1991–2017) and Health Professionals Follow-Up Study (1986–2016)
- Participants
- 203,644 women4,900,181 person-years
- Exposure
- Highest vs lowest quintiles of methyl donor nutrient intake
- Outcome
- Incident T2D
Methodological detailsthree U.S. cohorts (NHS, NHS2, HPFS), Cox proportional hazards models with time-varying covariates, inverse variance-weighted fixed-effects meta-analysis of cohort-specific hazard ratios (HRs), Dietary data collected every 2-4 years by semiquantitative food-frequency questionnaires
- Three U.S. cohorts (NHS, NHS2, HPFS)
- Cox proportional hazards models with time-varying covariates
- Inverse variance-weighted fixed-effects meta-analysis of cohort-specific HRs
- Dietary data collected every 2-4 years by semiquantitative food-frequency questionnaires
Main finding
As reported in the abstract
Highest quintile vs Lowest quintileHazard ratio (95% CI)
Total vitamin B2; multivariable-adjusted
0.93(0.89–0.98)
Total vitamin B6; multivariable-adjusted
0.93(0.89–0.97)
- Incident T2D cases
- 19,475
Observational data: associations, not effects.
Further findings
T2D risk by source of vitamin B2 and B6
- Significant associations remained for B2 from food but not from supplements
- Neither B6 from food nor B6 from supplements attained significance
Vitamin B12 intake and T2D risk
- B12 from food marginally associated with higher diabetes risk (HR)
- 1.05 [1.00-1.11]
- B12 from food after additional adjustment for red meat intake, no longer associated (HR)
- 1.04 [0.99-1.10]
- No association between total B12 intake and diabetes
Folate intake and T2D risk
- No evidence of association between folate intakes and diabetes
Original publication
Methyl Donor Nutrient Intake and Incidence of Type 2 Diabetes: Results From Three Large U.S. Cohorts. Diabetes Care. Published 29 August 2023. doi:10.
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