Efficacy of diabetes‐specific partial meal replacement on glycemic and weight control in type 2 diabetes: A randomized controlled trial
Primary result · HbA1c changeResult — go to the resultMD −0.63 % 95% CI −1.00 to −0.27Authors' conclusion
This study demonstrated that PMR with DSF significantly improved glycemic and weight management in participants with type 2 diabetes and overweight or obesity. Adiponectin levels increased in the treatment group, correlating with improved glycemic control. No adverse events were observed on liver and kidney profiles, highlighting its potential as a safe and effective approach for diabetes management.
Study context
- Population
- Adults aged 20–65 years with T2D (haemoglobin A1c (HbA1c) ≥7.5%) and overweight or obesity, Hospital Canselor Tuanku Muhriz, National University of Malaysia, February 2022 to March 2024; mean age 52.2 ± 9.7 years141 completed
- Participants
- 156 adults
- Comparison
- Diabetes-specific formula (DSF)-based partial meal replacement (PMR) plus dietary consultation vs dietary consultation alone
- Primary endpoint
- Mean change in HbA1c
- Follow-up
- Week 12
Methodological detailsparallel, single-centre
- Parallel
- Single-centre
Primary result
HbA1c change
MD
−0.63 %
95% CI −1.00 to −0.27
P < 0.001
Change by group
Treatment
−0.83
%
Control
−0.19
%
As reported in the abstract
Further findings
Clinically significant HbA1c reduction (≥0.5%)
P = 0.023
Fasting glucose, insulin and anthropometric measurements
- Significantly improved in the treatment group vs controls
Hormonal changes (subsample)
- Significant improvements in adiponectin levels in the treatment group
- Subsample analysis
Safety
- No adverse events observed on liver and kidney profiles
Original publication
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