Altered brain function and structure in youth-onset type 2 diabetes
Authors' conclusion
Y-T2D is associated with distinct alterations in brain function and structure, providing evidence of potentially compromised brain health in this clinical population.
Study context
- Population
- Young adults with Y-T2D (mean age 25.0 ± 7.2 years, diabetes duration 6.5 ± 6.7 years) and peers with obesity alone (age 19 ± 1.6 years) or healthy weight (age 22.9 ± 4.1 years)
- Participants
- 40 adults
- Exposure
- Youth-onset T2D vs obesity alone vs healthy weight
- Y-T2Dn = 12
- OBn = 8reference
- Healthy weight (HW)n = 20reference
- Outcome
- Brain function (functional connectivity, seed-to-voxel analysis) and structure (GM volume) on MRI
Main finding
As reported in the abstract
- Stronger functional connectivity between salience network and default mode network in Y-T2D vs both OB and HW
- Reduced gray matter (GM) volume in regions associated with executive functioning, language and visual processing in Y-T2D vs OB and HW
- Y-T2D vs OB: P < 0.05
- Y-T2D vs HW: P < 0.05
- Y-T2D vs OB: P < 0.001
- Y-T2D vs HW: P < 0.001
Observational data: associations, not effects.
Original publication
Altered brain function and structure in youth-onset type 2 diabetes. Eur J Endocrinol. Published 8 May 2025. doi:10.
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