Efficacy and Safety of Three‐Years Growth Hormone Treatment in Girls With Turner Syndrome and Growth Hormone Deficiency: A Case‐Control Study
Authors' conclusion
In conclusion, GH treatment in both TS and GHD girls is an effective, safe treatment for short stature, improving both height and growth rate, especially during the first year of treatment. Moreover, although growth outcomes were significantly better in GHD girls in the first year of treatment, over time no significant differences were observed between TS and GHD girls.
Study context
- Population
- Girls with turner syndrome (TS) or isolated idiopathic GH deficiency (GHD) treated with growth hormone (GH) for at least 36 months, age range 4.17–10.42 years
- Participants
- 20 participants
- Comparison
- 3-year GH treatment in TS vs GHD girls
- TSn = 10
- GHDn = 10reference
- Outcome
- Growth outcome and safety of GH treatment
- Follow-up
- 3 years
Methodological detailsmatched for age, Growth parameters, glycemic profile and IGF-1 collected every 6 months
- Matched for age
- Growth parameters, glycemic profile and IGF-1 collected every 6 months
Main finding
As reported in the abstract
Height increase (SDS), TS vs GHD · 6 and 12 months
- TS girls showed a lower height and a lower height increase throughout the study; significant only after 6 and 12 months
- TS vs GHD: P = 0.045
- TS vs GHD: P = 0.034
Observational data: associations, not effects.
Further findings
Height, weight and growth rate vs baseline · 3 years
- Significant improvement in both TS and GHD after 3 years (p ≤ 0.01), evident after 6 months (p ≤ 0.016)
Height increase between time points
- Both groups: significant increase 12 vs 6 months (p ≤ 0.008) and 24 vs 12 months (p ≤ 0.031)
- Only GHD: significant increase 36 vs 30 months (p = 0.035)
Safety
Adverse events during 3-year GH treatment
- Treatment was well tolerated; most frequent adverse event was autoimmune thyroiditis (two TS girls)
- 10%
- Transient hypertransaminasemia, one TS girl
- 5%
- Transient hypercholesterolemia, one GHD girl
- 5%
- No hyperglycemia occurred throughout the treatment
Original publication
Efficacy and Safety of Three‐Years Growth Hormone Treatment in Girls With Turner Syndrome and Growth Hormone Deficiency: A Case‐Control Study. Clin Endocrinol (Oxf). Published 22 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →