Growth Prediction Model for Prepubertal Children With Idiopathic Growth Hormone Deficiency: An Analysis of LG Growth Study Data
Authors' conclusion
GH treatment significantly improves height outcomes in prepubertal children with GHD. The developed predictive models demonstrated accuracy, facilitating personalized GH therapy. Future research should focus on refining these models and exploring the long-term effects of GH treatment in pubertal patients.
Study context
- Population
- Prepubertal children with idiopathic GH deficiency (GHD) from the LG growth study (LGS) registry treated with growth hormone (GH) ≥2 years; mean age 6.0 ± 1.8 years
- Participants
- 669 children
- Outcome
- Prediction model for GH treatment response (height SDS change)
- Follow-up
- First 2 years
Methodological detailsprediction model development and validation, stepwise multivariate regression, Clinical and laboratory data collected at baseline and every 6 months
- Prediction model development and validation
- Stepwise multivariate regression
- Clinical and laboratory data collected at baseline and every 6 months
Main finding
As reported in the abstract
Variability in height SDS change explained by prediction models (age, birth weight, bone age, initial height SDS, BMI SDS, mid-parental height, GH dose, first year of height after GH)
Variability explained, first year
76.9%
Variability explained, second year
84.1%
Observational data: associations, not effects.
Further findings
Height standard deviation score (SDS) · baseline, first year, second year
- Height SDS at baseline (mean ± SD)
- −2.50 ± 0.71
- Height SDS in first year (mean ± SD)
- −1.66 ± 0.71
- Height SDS in second year (mean ± SD)
- −1.35 ± 0.71
- Significant increase
Growth velocity · first and second year
- First-year growth velocity (mean ± SD)
- 9.06 ± 1.51 cm
- Second-year growth velocity (mean ± SD)
- 7.42 ± 1.37 cm
Original publication
Growth Prediction Model for Prepubertal Children With Idiopathic Growth Hormone Deficiency: An Analysis of LG Growth Study Data. Clin Endocrinol (Oxf). Published 15 December 2024. doi:10.
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