Growth Hormone Deficiency and Subsequent Replacement Therapy Trigger Differential Expression of Specific MicroRNAs in Males and Females: Not Just a Matter of Height
Authors' conclusion
Overall, in addition to the shared changes previously documented by our group, this study shows that prepubertal males and females with isolated idiopathic GHD have distinct miRNA profiles before and after 3 months on GHT, suggesting gender effects that are not currently taken into consideration while treating pediatric patients.
Study context
- Population
- Prepubertal children with isolated idiopathic GH deficiency (GHD)
- Comparison
- miRNA profiles in females vs males with GHD, before and after 3 months of GH therapy (GHT)
- Primary endpoint
- Gender-specific changes in miRNA profile
- Follow-up
- Before and after 3 months on GHT
Methodological detailsGSE193450, re-analysis, pathway enrichment analysis, sex-stratified
- GSE193450
- Re-analysis
- Pathway enrichment analysis
- Sex-stratified
Primary result
As reported in the abstract
Significantly upregulated miRNAs · before start of GHT
- Females: 3 microRNAs (miRNAs) significantly upregulated (hsa-miR-185-5p, hsa-miR-380-3p, hsa-miR-486-5p)
- Males: 9 miRNAs significantly upregulated (hsa-miR-30b-5p, hsa-miR-30c-5p, hsa-miR-132-3p, hsa-miR-139-5p, hsa-miR-142-5p, hsa-miR-195-5p, hsa-miR-197-3p, hsa-miR-200c-3p, hsa-miR-340-5p)
Further findings
Significantly upregulated miRNAs · after 3 months of GHT
- Females: 3 miRNAs significantly upregulated (hsa-miR-124-3p, hsa-miR-215-5p, hsa-miR-525-3p)
- Males: 4 miRNAs significantly upregulated (hsa-miR-30c-5p, hsa-miR-30e-5p, hsa-miR-551b-3p, hsa-miR-671-3p)
Pathway enrichment
- Most affected pathways included Wnt, TGFβ, Jak-STAT and p53 signaling
Original publication
Growth Hormone Deficiency and Subsequent Replacement Therapy Trigger Differential Expression of Specific MicroRNAs in Males and Females: Not Just a Matter of Height. Horm Res Paediatr. Published 20 March 2026. doi:10.
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