Increased insulin-like growth factor-1 concentrations in paediatric suprasellar low-grade glioma: an international multicentre study
Authors' conclusion
Increased IGF-1 concentrations are commonly observed in children with suprasellar LGG, especially in younger children, those with an NF1 mutation, or during underweight. Elevation of IGF-1 can resolve over time, and the absence of an effect on final height or on tumour progressions seems reassuring.
Study context
- Population
- Children diagnosed with suprasellar low-grade glioma (LGG) under age 18, 2003–2023, Netherlands and UK, ≥1-year follow-up; median age at diagnosis 3.8 years (IQR 1.7–7.1)
- Participants
- 235 children
- Outcome
- Prevalence of elevated IGF-1 (IGF-1 SDS >+2.0 for age and biological sex, without GH use)
Methodological detailsinternational, multicentre
- International
- Multicentre
Main finding
As reported in the abstract
Elevated IGF-1 at any time point
73 patients
31.1%
Elevated IGF-1 at tumour diagnosis (138 children tested)
15.2%
Observational data: associations, not effects.
Further findings
Factors associated with elevated IGF-1
- Younger age at tumour diagnosis
- P = 0.004
- Neurofibromatosis type 1 (NF1)
- P = 0.028
- Diencephalic syndrome
- P = 0.047
Spontaneous normalization of IGF-1 over time
- IGF-1 normalized spontaneously among 73 with elevated IGF-1
- 55 (75.3%)
Final height standard deviation score (SDS) corrected for target height SDS
- Not associated with having had elevated IGF-1
- P = 0.113
Tumour progressions
- No difference in the number of tumour progressions
Original publication
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