Salivary Testosterone, Androstenedione and 11‐Oxygenated 19‐Carbon Concentrations Differ by Age and Sex in Children
Authors' conclusion
For the first time we describe the physiological profile of 11KT and 11OHA4 in children. Further data are required to establish reference ranges, which should consider age, sex, pubertal status and time of sampling.
Study context
- Population
- Healthy children aged 10.4 ± 3.9 (5.0–17.5) years; saliva collected 30 min after waking and every 2 h until bedtime30 male
- Participants
- 52 children
- Outcome
- Salivary T, A4, 11KT and 11OHA4 by age, sex and puberty
Methodological detailsSaliva analysed by liquid chromatography tandem mass spectrometry
- Saliva analysed by liquid chromatography tandem mass spectrometry
Main finding
As reported in the abstract
- Salivary T higher in postpubertal children, particularly boys
- p < 0.001
- Salivary A4 lower in boys vs girls; no difference with pubertal development
- p = 0.009
- 11KT increased with age; similar between boys and girls
- p < 0.001
- 11OHA4 decreased with age; below detectable limits after early morning peak in both sexes
- p = 0.03
Further findings
Anthropometry
- Median height SDS
- 0.4 (IQR −0.3 to 1.01)
- Median BMI SDS
- 0.3 (IQR −0.2 to 1.3)
Original publication
Salivary Testosterone, Androstenedione and 11‐Oxygenated 19‐Carbon Concentrations Differ by Age and Sex in Children. Clin Endocrinol (Oxf). Published 20 May 2025. doi:10.
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