Obesity

Effects of Time‐Restricted Eating on Gut Microbiota and Metabolites and Their Relationship With Cardiometabolic Risk Factors

Obesity (Silver Spring)Published Randomised controlled trial

Authors' conclusion

Time-restricted eating may be beneficial to weight loss and cardiometabolic health improvement by regulating gut microbiota and serum metabolites.

Study context

Population
Young adults with overweight or obesity
Participants
60 adults
Comparison
6-h eTRE vs 6-h lTRE vs control
Methodological details8-week
  • 8-week

Primary result

As reported in the abstract

Gut microbiota abundance (16S rRNA sequencing) vs control · 8 weeks
  • eTRE vs Control: P < 0.05
  • lTRE vs Control: P < 0.05

Further findings

Differential serum metabolites (liquid chromatography-mass spectrometry (LC-MS)) and cardiometabolic risk factors

Differential serum metabolites (e.g., L-malic acid in eTRE; isovaleric acid in lTRE) significantly associated with changes in weight, body fat and systolic blood pressure (SBP)
P < 0.05

Original publication

Effects of Time‐Restricted Eating on Gut Microbiota and Metabolites and Their Relationship With Cardiometabolic Risk Factors. Obesity (Silver Spring). Published 8 May 2026. doi:10.1002/oby.70207

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