Thyroid disease

Effects of Overweight on Risk of Thyroid Nodules in Children and Adolescents: The Fukushima Health Management Survey

J Clin Endocrinol MetabPublished Population-based prospective cohort study

Main finding · New thyroid nodulesResult — go to the resultAdjusted odds ratio 1.27 95% CI 1.04–1.57

Authors' conclusion

Being overweight was associated with thyroid nodules in children and adolescents, mostly adolescent females, regardless of their proximity to the nuclear power plant.

Study context

Population
Children and adolescents without thyroid nodules in the first 2 thyroid US examinations of the Fukushima Health Management Survey after a nuclear accidentfinalized for analysis
Participants
184,519 children
Exposure
Overweight vs normal weight
Outcome
New detected thyroid nodules at the third examination (6-7 years postaccident)
Follow-up
Average 4.2 years

Main finding

New thyroid nodules

Adjusted odds ratio

1.27

95% CI 1.04–1.57

Overweightvs Normal weight
aOR 1.27 (95% CI 1.04–1.57)

As reported in the abstract

New thyroid nodules detected
660 participants

Observational data: associations, not effects.

Further findings

New thyroid nodules by sex

aOR, overweight males
1.21
aOR, overweight females
1.32

New thyroid nodules by age group (0-9, 10-14, 15-19 years)

aOR range across age groups
1.17 to 1.75

Original publication

Effects of Overweight on Risk of Thyroid Nodules in Children and Adolescents: The Fukushima Health Management Survey. J Clin Endocrinol Metab. Published 13 March 2024. doi:10.1210/clinem/dgae161

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