Prospective Multicenter Registry–Based Study on Thyroid Storm: The Guidelines for Management From Japan Are Useful
Authors' conclusion
Prognosis seemed better than in the previous nationwide survey, even though disease severity was higher. The mortality rate was lower when the guidelines were followed. Thus, the guidelines are useful for managing TS.
Study context
- Population
- Patients with new-onset thyroid storm (TS) registered in Research Electronic Data Capture (REDCap)
- Participants
- 110 patients
- Exposure
- Management per 2016 JTA/JES TS guidelines followed vs not followed
- Outcome
- Mortality
- Follow-up
- Day 30
Main finding
As reported in the abstract
Mortality rate
Mortality rate at day 30 (vs 10.7% in previous nationwide survey)
5.5%
Observational data: associations, not effects.
Further findings
Mortality in patients with APACHE II score ≥ 12 · significantly higher when guidelines not followed
P = 0.01
Acute Physiology and Chronic Health Evaluation (APACHE) II score
- Median APACHE II score, higher than previous nationwide study (10); P = .001
- 13
Factors associated with poor prognosis at day 30
- Lower BMI, shock and lower left ventricular ejection fraction positively associated with poor prognosis; lack of fever ≥ 38 °C related to the outcome
Original publication
Prospective Multicenter Registry–Based Study on Thyroid Storm: The Guidelines for Management From Japan Are Useful. J Clin Endocrinol Metab. Published 8 March 2024. doi:10.
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