Does iodine fortification affect the risk of atrial fibrillation in incident hyperthyroidism? A national register‐based cohort
Main finding · RR of AF by calendar yearResult — go to the resultRelative risk 0.76 CI 0.62–0.94Authors' conclusion
Results indicate that IF may reduce the risk of concomitant AF in hyperthyroid patients. If these results are confirmed, IF may not only reduce the population incidence of hyperthyroidism but also reduce the burden of morbidity in the remaining hyperthyroid patients.
Study context
- Population
- Patients with incident hyperthyroidism (first inpatient or outpatient diagnosis), Danish nationwide registers, 1997–2018
- Participants
- 62,201 patients
- Exposure
- Atrial fibrillation (AF) risk by calendar year before vs after iodine fortification
- Outcome
- AF diagnosis within 3 months before to 6 months after the index date; RR of AF each calendar year
Methodological detailsnational, Danish nationwide registers, Poisson regression adjusted for age, sex, educational level, geographic region and comorbidities
- National
- Danish nationwide registers
- Poisson regression adjusted for age, sex, educational level, geographic region and comorbidities
Main finding
RR of AF by calendar year
Relative risk
0.76
CI 0.62–0.94
2017vs 1997
RR 0.76 (CI 0.62–0.94)
As reported in the abstract
Observational data: associations, not effects.
Further findings
AF overall
- Diagnosed with AF
- 7.9%
AF risk development by sex, age group or geographic region
- No statistically significant differences by sex, age group or geographic region
Original publication
Does iodine fortification affect the risk of atrial fibrillation in incident hyperthyroidism? A national register‐based cohort. Clin Endocrinol (Oxf). Published 4 March 2024. doi:10.
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