Hyperthyroidism and the risk of non-thyroid cancer: a Danish register-based long-term follow-up study
Main finding · All-cause cancerResult — go to the resultSubdistribution hazard ratio 1.12 95% CI 1.10–1.14Authors' conclusion
In this register-based study, patients with hyperthyroidism had an increased risk of cancer, in particular lung, prostate, and breast cancer. Whether a causal link exists remains to be proven.
Study context
- Population
- Danish nationwide registers; individuals with a diagnosis of hyperthyroidism and age- and sex-matched reference individualsmatched cohort
- Participants
- 95,469 vs 364,494
- Exposure
- Hyperthyroidism vs matched reference individuals
- Hyperthyroidismn = 95,469
- Reference individualsn = 364,494reference
- Outcome
- Subsequent all-cause cancer diagnosis
- Follow-up
- Median 10.9 years (range: 5.2-17.2) hyperthyroidism; 11.2 years (range: 5.4-17.4) reference
Methodological detailsmatched on age and sex, four reference individuals per case, Fine and Gray competing risk regression, adjusted for preexisting morbidity
- Matched on age and sex
- Four reference individuals per case
- Fine and Gray competing risk regression
- Adjusted for preexisting morbidity
Main finding
All-cause cancer
Subdistribution hazard ratio
1.12
95% CI 1.10–1.14
Hyperthyroidismvs Reference individuals
SHR 1.12 (95% CI 1.10–1.14)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | SHR (95% CI) | |
|---|---|---|
| Breast cancer | 1.07 (1.02–1.13) | |
| Lung cancer | 1.20 (1.16–1.26) | |
| Prostate cancer | 1.10 (1.02–1.19) | |
| Colorectal cancerNot increased | 1.04 (0.99–1.09) | |
| 0.512Subdistribution hazard ratio (log scale) |
Sub-analyses by age at hyperthyroidism diagnosis and cause of hyperthyroidism
- Sub-analyses stratified for age at diagnosis and cause of hyperthyroidism yielded similar results
Original publication
Hyperthyroidism and the risk of non-thyroid cancer: a Danish register-based long-term follow-up study. Eur Thyroid J. Published 1 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →