Thyroid disease in pregnancy and the risk of venous thromboembolism: a Danish nationwide cohort study
Authors' conclusion
In a large, nationwide cohort, an association between maternal thyroid disease and VTE diagnosed in relation to pregnancy was found. Results point towards maternal hyperthyroidism as the predominant risk factor for thrombosis and draw attention to confounding factors in the association with hypothyroidism.
Study context
- Population
- Pregnancies in Denmark 1999–2015, nationwide health registers on diagnoses and medications
- Participants
- 1,149,871 pregnancies
- Exposure
- Maternal hyperthyroidism or hypothyroidism vs no thyroid disease
- Hyperthyroidismn = 12,633
- Hypothyroidismn = 17,940
- Outcome
- Venous thromboembolism (VTE) during pregnancy and up to one year after the pregnancy had ended
Methodological detailsnationwide, register-based
- Nationwide
- Register-based
Main finding
As reported in the abstract
VTE
Each group vs non-exposedAdjusted odds ratio (95% CI)
Hyperthyroidism
1.39(1.06–1.83)
Hypothyroidism
1.43(1.14–1.79)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| VTE, additionally adjusted for pre-pregnancy BMIHyperthyroidismvs Non-exposed | 1.47 (1.08–2.01) | |
| VTE, additionally adjusted for pre-pregnancy BMIHypothyroidismvs Non-exposed | 1.25 (0.96–1.62) | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Thyroid disease in pregnancy and the risk of venous thromboembolism: a Danish nationwide cohort study. Eur Thyroid J. Published 31 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →