Management of Maternal Hypothyroidism in Pregnancy: A Danish Regional Study
Authors' conclusion
In a Danish regional cohort of pregnant women with hypothyroidism, biochemical monitoring of thyroid function was often performed and was mostly followed by a change in the dose of L-T4 in early pregnancy ( ~ 50% of the women) and rarely in late pregnancy ( ~ 10% of the women).
Study context
- Population
- Pregnant women with known hypothyroidism treated with LT4 before pregnancy, managed in Departments of Endocrinology, North Denmark Region, 2022–2024
- Participants
- 175 women
- Outcome
- Frequency of biochemical monitoring and LT4 dose adjustments
Methodological detailsregional, Review of medical records
- Regional
- Review of medical records
Main finding
As reported in the abstract
Dose adjustment following biochemical control, by pregnancy period
Up to and including week 12: 84 of 166
50.6%
95% CI 42.7%–58.4%
Weeks 13–24: 35 of 164
21.3%
95% CI 15.3%–28.4%
Week 25 onwards: 17 of 165
10.3%
95% CI 6.1%–16.0%
Number of thyroid-stimulating hormone (TSH) monitorings in pregnancy, range 1 to 12
median 7 times
Observational data: associations, not effects.
Original publication
Management of Maternal Hypothyroidism in Pregnancy: A Danish Regional Study. Clin Endocrinol (Oxf). Published 4 May 2025. doi:10.
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