Hyperthyroidism in Danish Pregnant Women During a 20-Year Period
Main finding · Treatment with ATDs in pregnancyResult — go to the resultAdjusted odds ratio 1.51 95% CI 1.30–1.74Authors' conclusion
The use of ATDs in Danish pregnant women increased following the implementation of IF and then leveled out. Results comply with observations in the general Danish population and suggest that IF influences the occurrence of autoimmune hyperthyroidism in younger individuals.
Study context
- Population
- Danish pregnant women, nationwide register-based cohort (1997–2016); Danish National Birth Cohort (1997–2003) and North Denmark Region Pregnancy Cohort (2011–2015)
- Exposure
- After vs before mandatory iodine fortification
- Outcome
- Maternal use of ATDs in pregnancy and frequency of early pregnancy biochemical hyperthyroidism
Methodological detailsnationwide, 2 birth cohorts with biochemical data
- Nationwide
- 2 birth cohorts with biochemical data
Main finding
Treatment with ATDs in pregnancy
Adjusted odds ratio
1.51
95% CI 1.30–1.74
After IF (2001-2004)vs Baseline (1997-1999)
aOR 1.51 (95% CI 1.30–1.74)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Treatment with ATDs, West Denmark (previously moderately iodine-deficient)After IF (2001-2004)vs Baseline (1997-1999) | 1.67 (1.36–2.04) | |
| Treatment with ATDs, East Denmark (mildly deficient)After IF (2001-2004)vs Baseline (1997-1999) | 1.30 (1.06–1.60) | |
| 0.512Adjusted odds ratio (log scale) |
Treatment with antithyroid drugs (ATDs) at end of follow-up
- Returned to baseline levels in both regions
Early pregnancy biochemical hyperthyroidism
- No time-related difference observed
Original publication
Hyperthyroidism in Danish Pregnant Women During a 20-Year Period. J Clin Endocrinol Metab. Published 12 July 2023. doi:10.
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