Minimally Invasive Treatments of Benign Thyroid Nodules: A Network Meta-Analysis of Short-Term Outcomes
Authors' conclusion
We have comprehensively reviewed the published literature on the efficacy and safety of thermal ablation modalities for benign thyroid nodules.
Study context
- Population
- Patients with benign nodular thyroid disease treated with thermal ablation or surgery
- Participants
- 4,112 patients16 studies
- Comparison
- Thermal ablation vs conventional surgery
- Outcome
- Volume reduction rate (VRR), symptomatic score and cosmetic score improvement
Methodological details3 RCTs and 13 comparative case series
- 3 RCTs and 13 comparative case series
Pooled result
As reported in the abstract
VRR, symptomatic score and cosmetic score · mean follow-up 11.9 months
| Group | Surface under the cumulative ranking area (SUCRA) |
|---|---|
| CS | 98.49 |
| Laser ablation (LA) | 51.58 |
| Microwave ablation (MWA) | 57.0 |
Surface under the cumulative ranking area (SUCRA)
CS98.49
Laser ablation (LA)51.58
Microwave ablation (MWA)57.0
Further pooled results
| Outcome | RR (CrI) |
|---|---|
| Nodular regrowthRFA vs CS · CrI | 0.09 (0.00–0.85) |
Safety
| Outcome | Values | RR | |
|---|---|---|---|
| Postintervention vocal complicationsRFAvs CSCrI · RFA ranked highest in safety | RFA SUCRA 61.62 | 0.19 (95% CrI 0.06–0.48) | |
| Postintervention vocal complicationsLAvs CSCrI · RFA ranked highest in safety | 0.23 (95% CrI 0.06–0.79) | ||
| Postintervention vocal complicationsMWAvs CSCrI · RFA ranked highest in safety | 0.25 (95% CrI 0.09–0.60) | ||
| Transient laryngeal nerve injuryMWAvs CSCrI | 0.16 (CrI 0.02–0.73) | ||
| 0.050.21520Relative risk (log scale) |
| Outcome | Values | RR (CrI) |
|---|---|---|
| Transient laryngeal nerve injuryRFA vs CS · CrI | 0.05 (0.00–0.40) | |
| HypothyroidismRFA vs CS · CrI · RFA highest safety ranking | RFA SUCRA 99.86 | 0.00 (0.00–0.00) |
| HypothyroidismMWA vs CS · CrI · RFA highest safety ranking | 0.00 (0.00–0.03) |
Original publication
Minimally Invasive Treatments of Benign Thyroid Nodules: A Network Meta-Analysis of Short-Term Outcomes. Thyroid. Published 10 July 2023. doi:10.
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