The 2023 Bethesda System for Reporting Thyroid Cytopathology
Methodological detailsthird edition
- Third edition
Recommendations
As issued by the authors
A single name for each of the 6 diagnostic categories: (i) nondiagnostic; (ii) benign; (iii) atypia of undetermined significance; (iv) follicular neoplasm; (v) suspicious for malignancy; (vi) malignant
Each category has an implied risk of malignancy (ROM), updated and refined on data reported after the second edition; an average ROM is given for each category, plus the expected range of cancer risk
Atypia of undetermined significance subcategorization simplified into 2 subgroups based on implied ROM and molecular profiling
Pediatric thyroid disease discussion added, with pediatric ROMs and management algorithms
Nomenclature updated to align with the 2022 WHO Classification of Thyroid Neoplasms
Two new chapters: molecular and ancillary testing in thyroid cytopathology; clinical perspectives and imaging findings in thyroid disease
Original publication
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