Clinical Outcomes of Thermal Ablation Re-Treatment of Benign Thyroid Nodules: A Multicenter Study from the Italian Minimally Invasive Treatments of the Thyroid Group
Authors' conclusion
Best results were seen in small and medium nodules (<30 mL) and after RFA.
Study context
- Population
- Patients with symptomatic benign thyroid nodules whose volume decreased by <50% after initial thermal ablation (TA) (technique inefficacy)
- Participants
- 135 patients
- Exposure
- TA re-treatment vs first TA treatment
- Outcome
- Volume and volume reduction ratio (VRR) over time; 6- and 12-month VRR after first vs second treatment
- Follow-up
- 6 and 12 months
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
VRR after re-treatment
| Group | Value | VRR at 6 months | VRR at 12 months |
|---|---|---|---|
| Re-treatment | 50% | 50% | 52.2% |
Re-treatment
Value50%
VRR at 6 months50%
VRR at 12 months52.2%
Observational data: associations, not effects.
Further findings
Factors for technique inefficacy, further treatments and re-treatment
| HR (CI) | ||
|---|---|---|
| RFATechnique inefficacy; adjusted | 0.40 (0.24–0.65) | |
| RFANeed of further treatments; adjusted | 0.30 (0.12–0.76) | |
| Large nodule volume (>30 mL)Risk of re-treatment; adjusted | 4.52 (1.38–14.82) | |
| 0.050.21520Hazard ratio (log scale) |
Rates after re-treatment
- Technique inefficacy rate
- 51.9%
- Regrowth rate
- 12.6%
- Further treatment rate
- 15.6%
Original publication
Clinical Outcomes of Thermal Ablation Re-Treatment of Benign Thyroid Nodules: A Multicenter Study from the Italian Minimally Invasive Treatments of the Thyroid Group. Thyroid. Published 27 December 2023. doi:10.
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