The Effect of Substituting Water for Artificially Sweetened Beverages on Glycemic and Weight Measures in People With Type 2 Diabetes: The Study of Drinks With Artificial Sweeteners (SODAS), a Randomized Trial
Primary result · Change in HbA1cResult — go to the resultMean difference in change 0.29 %Authors' conclusion
For people with T2D and HbA1c <8.5% who regularly consume ASBs, this trial provided no evidence that substituting water would improve glycemic-related clinical care measures over 24 weeks.
Study context
- Population
- Adults with T2D (HbA1c 6.5–8.5%; aged ≥35 years) who regularly consumed commercial artificial sweetened beverage (ASBs)179 with complete data
- Participants
- 181 adults
- Comparison
- Water vs habitual ASB
- Primary endpoint
- HbA1c
- Follow-up
- 24 weeks
Methodological detailstwo-arm, parallel, 2-week run-in, two academic health centers
- Two-arm
- Parallel
- 2-week run-in
- Two academic health centers
Primary result
Change in HbA1c · baseline to 24 weeks
Mean difference in change
0.29 %
P = 0.013
As reported in the abstract
Further findings
Secondary clinical measures (fructosamine, fasting glucose and insulin, body weight, CGM metrics)
- No significant effects; directionally consistent with primary results
Original publication
The Effect of Substituting Water for Artificially Sweetened Beverages on Glycemic and Weight Measures in People With Type 2 Diabetes: The Study of Drinks With Artificial Sweeteners (SODAS), a Randomized Trial. Diabetes Care. Published 10 December 2025. doi:10.
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