Clinical implications of intentional weight loss in people living with type 2 diabetes: A real‐world database study
Authors' conclusion
A reduction in BMI and HbA1c by intentional weight loss, independently and concomitantly, was associated with a reduced risk of microvascular and macrovascular complications in people with obesity and T2D.
Study context
- Population
- Adults with obesity (BMI ≥30 kg/m²) and T2D, Clinical Practice Research Datalink (CPRD) Aurum database 2006–2022; mean age 53.3 years, 58% male
- Participants
- 100,507 adults
- Exposure
- Per 1% BMI reduction and per 1%-point HbA1c decrease after 4-year intentional weight loss period
- Outcome
- Composite microvascular (retinopathy, neuropathy, CKD) and macrovascular (MI, PAD, stroke) complications
- Follow-up
- Following a 4-year intentional weight loss period
Methodological detailsreal-world database (CPRD Aurum), Cox proportional hazard regression
- Real-world database (CPRD Aurum)
- Cox proportional hazard regression
Main finding
As reported in the abstract
Microvascular complications, HR per 1% BMI reduction
0.990
95% CI 0.988, 0.992
Macrovascular complications, HR per 1% BMI reduction
0.996
95% CI 0.994, 0.998
Microvascular complications, HR per 1%-point HbA1c decrease
0.875
95% CI 0.866, 0.884
Macrovascular complications, HR per 1%-point HbA1c decrease
0.872
95% CI 0.862, 0.883
Observational data: associations, not effects.
Further findings
Change in BMI and HbA1c
- Mean [SD] relative reduction in BMI
- −2.2% [9.1%]
- Mean [SD] absolute change in HbA1c
- 0.0% [1.9%]
Individual complications
- Reductions in BMI and HbA1c associated with reduced risk of retinopathy, neuropathy, CKD and PAD
- Reductions in HbA1c only associated with reduced risk of MI and stroke
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →