Effect of an Intermittent Calorie-restricted Diet on Type 2 Diabetes Remission: A Randomized Controlled Trial
Primary result · Diabetes remission (HbA1c <48 mmol/mol (<6.5%) for ≥3 months after discontinuing all antidiabetic medications)Result — go to the resultOR for diabetes remission 31.32 95% CI 2.39–121.07Authors' conclusion
This study demonstrated the clinical efficacy of CMNT in achieving diabetes remission for at least 1 year.
Study context
- Population
- Adults aged 38–72 years with T2D for 1 to 11 years, body mass index (BMI) 19.1 to 30.4, 66.7% male, on antidiabetic agents and/or insulin
- Participants
- 36 vs 36
- Comparison
- Chinese Medical Nutrition Therapy vs control
- Chinese Medical Nutrition Therapy (CMNT)n = 36
- Controln = 36reference
- Primary endpoint
- Diabetes remission: stable HbA1c <48 mmol/mol (<6.5%) for ≥3 months after discontinuing all antidiabetic medications
- Follow-up
- 3-month intervention plus 3-month follow-up
Methodological detailsrandomized 1:1
- Randomized 1:1
Primary result
As reported in the abstract
Diabetes remission (HbA1c <48 mmol/mol (<6.5%) for ≥3 months after discontinuing all antidiabetic medications)
OR for diabetes remission
31.32
95% CI 2.39–121.07
P < 0.0001
Events by treatment group
CMNTvs Control
OR for diabetes remission 31.32 (95% CI 2.39–121.07); P < 0.0001
Secondary outcomes
| Outcome | CMNT | Control |
|---|---|---|
| Body weight reductionMean, kg | 5.93 (SD 2.47) | 0.27 (SD 1.43) |
| Medication costs | 60.4/month | 265.1/month |
- Medication costs — Medication costs lower with CMNT than control
- 77.22%
Sustained remission · 12-month follow-up
- Participants with sustained remission
- 44.4% (16/36)
- Hemoglobin A1c (HbA1c) in sustained remission (SD 0.87)
- 6.33%
Original publication
Effect of an Intermittent Calorie-restricted Diet on Type 2 Diabetes Remission: A Randomized Controlled Trial. J Clin Endocrinol Metab. Published 14 December 2022. doi:10.
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