The association between triglyceride-glucose (TyG) index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study
Authors' conclusion
The use of antidiabetic and hypolipidemic agents modify the association between the TyG index and all-cause and CVD mortality. These findings suggest that future studies on the TyG index and its relationship with CVD and mortality should account for the modifying effects of these agents.
Study context
- Population
- Adults from the National Health and Nutrition Examination Survey (1999–2018); weighted mean age 61.08 years [SE: 0.24]; 49.35% femalerepresenting 42,753,806 individuals
- Participants
- 5,046 adults
- Exposure
- TyG index–mortality association in users vs non-users of antidiabetic and hypolipidemic agents
- Outcome
- CVD mortality (and all-cause mortality)
- Follow-up
- Until December 31, 2019
Methodological detailsNHANES 1999-2018, linkage with National Death Index, Medication use self-reported
- NHANES 1999-2018
- Linkage with National Death Index
- Medication use self-reported
Main finding
As reported in the abstract
- TyG index significantly associated with all-cause and cardiovascular disease (CVD) mortality; associations modified by use of antidiabetic and hypolipidemic agents
- p < 0.01
Observational data: associations, not effects.
Original publication
The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study. Cardiovasc Diabetol. Published 7 February 2025. doi:10.
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