Remission of type 2 diabetes depends on time since diagnosis and low-calorie diet composition: Results of a randomized controlled trial in individuals with overweight and obesity
Authors' conclusion
Fasting plasma glucose, C-peptide levels, diabetes duration, and used macronutrient profile emerged as important factors for the achievement of T2DR, although a considerable remission is still possible after long duration of type 2 diabetes.
Study context
- Population
- Adults with T2D and BMI > 27 kg/m², diabetes duration ≤ 4 years or ≥ 8 years; antidiabetic medication discontinued
- Participants
- 47 adults
- Comparison
- Two very low-calorie diets (VLCDs) with slightly different macronutrient composition; short vs long diabetes duration
- Primary endpoint
- T2D remission (T2DR), defined as fasting plasma glucose < 126 mg/dl
- Follow-up
- After 3-month VLCD
Primary result
As reported in the abstract
T2DR (fasting plasma glucose < 126 mg/dl) · 3 months
T2DR achieved, all participants
34 of 47
72%
Further findings
| Outcome | Short duration | Long duration | P value |
|---|---|---|---|
| Weight loss · 3 monthsSimilar weight loss | −15.2 ± 5.8 kg | −13.9 ± 4.8 kg | P = 0.473 |
Baseline predictors of T2DR
- Those achieving T2DR had significantly lower fasting plasma glucose and higher C-peptide levels at baseline
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Remission of type 2 diabetes depends on time since diagnosis and low-calorie diet composition: Results of a randomized controlled trial in individuals with overweight and obesity. Diabetes Res Clin Pract. Published 14 February 2026. doi:10.
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