Early origins of metabolic and overall health in young adults: An outcome-wide analysis in a general cohort population

Amadou, C; Heude, B; de Lauzon-Guillain, B; Lioret, S; Descarpentrie, A; Ribet, C; Zins, M; Charles, MA

doi:10.1016/j.diabet.2022.101414

Lipids & metabolic liver disease

Early origins of metabolic and overall health in young adults: An outcome-wide analysis in a general cohort population

Diabetes MetabPublished 6 Dec 2022Prospective cohort study

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Authors' conclusion

Extreme BW is associated with long-term health. It should be considered in the personalized prevention of cardiometabolic, respiratory, and mental health conditions in adulthood, especially in socio-economically disadvantaged populations.

Study context

Population: Participants under 60 years with a reliable birth weight (BW) from the French nationwide Constances cohort
Participants: 73,315 participants

Exposure: Low and high birth weight vs normal birth weight
Outcome: Associations of extreme BW with adult outcomes (RR [95% CI])

Methodological detailsoutcome-wide analysis, nationwide, sex-stratified modified Poisson regression, adjusted for age, maternal health history, geographical origins and parents' occupation

Outcome-wide analysis
Nationwide
Sex-stratified modified Poisson regression
Adjusted for age, maternal health history, geographical origins and parents' occupation

Main finding

As reported in the abstract

Relative risk (95% CI)

LBWmen; fasting glucose impairment

1.33(1.16–1.52)

LBWmen; hypertriglyceridemia

1.27(1.17–1.37)

LBWmen; high blood pressure

1.15(1.07–1.24)

LBWmen; NAFLD

1.13(1.02–1.24)

LBWmen; high LDL-C

1.12(1.05–1.21)

LBWmen; anxiety

1.12(1.01–1.24)

LBWmen; depression

1.09(1.00–1.18)

HBWmen; obesity

1.21(1.08–1.35)

LBWwomen; fasting glucose impairment

1.31(1.12–1.54)

LBWwomen; high blood pressure

1.27(1.16–1.4)

LBWwomen; hypertriglyceridemia

1.20(1.05–1.36)

LBWwomen; anxiety

1.10(1.03–1.17)

LBWwomen; asthma

1.09(1–1.19)

HBWwomen; obesity

1.24(1.13–1.36)

HBWwomen; NAFLD

1.20(1.06–1.37)

Observational data: associations, not effects.

Further findings

Mean BW (10th–90th percentile)

g

Men: 3390 (2800-4000)
Women: 3247 (2680-3820)

Tertiary education attainment

LBW and HBW associated with lesser likelihood of tertiary education in both sexes
Education level was a significant partial mediator of the LBW–outcome association

Original publication

Early origins of metabolic and overall health in young adults: An outcome-wide analysis in a general cohort population. Diabetes Metab. Published 6 December 2022. doi:10.1016/j.diabet.2022.101414

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