Lipids & metabolic liver disease
Glucagon-like Peptide-2 Acutely Enhances Chylomicron Secretion in Humans Without Mobilizing Cytoplasmic Lipid Droplets
Authors' conclusion
Unlike glucose that mobilizes enterocyte CLDs and enhances CM secretion, GLP-2 acutely increased plasma CMs without significant mobilization of CLDs, supporting our previous findings that GLP-2 does not act directly on enterocytes to enhance CM secretion and most likely mobilizes secreted CMs in the lamina propria and lymphatics.
Study context
- Population
- Humans after ingesting a high-fat bolus; plasma sampling in 1 subset, duodenal biopsy in another
- Comparison
- GLP-2 vs placebo
- Outcome
- Plasma lipids and duodenal cytoplasmic lipid droplets (CLDs)
Methodological detailsplacebo-controlled, single subcutaneous dose
- Placebo-controlled
- Single subcutaneous dose
Main finding
As reported in the abstract
Plasma TG increased with GLP-2
46%
P = 0.009
TG in chylomicron (CM)-sized particles increased with GLP-2
133%
P = 0.003
Further findings
Proteomic analysis
- Several proteins of interest identified that require further investigation
Original publication
Glucagon-like Peptide-2 Acutely Enhances Chylomicron Secretion in Humans Without Mobilizing Cytoplasmic Lipid Droplets. J Clin Endocrinol Metab. Published 2 December 2022. doi:10.
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