Dynapenic abdominal obesity is associated with long-term cognitive trajectories and mild cognitive impairment
Authors' conclusion
D/AO is associated with long-term lower cognition and MCI in middle-aged and older patients, making it a potentially valuable tool for early intervention in dementia prevention.
Study context
- Population
- Individuals aged 45 years and over, China Health and Retirement Longitudinal Study (CHARLS, 2015–2020)
- Participants
- 6,698 individuals
- Exposure
- D/AO, D/NAO and ND/AO vs ND/NAO
- Outcome
- Cognitive function trajectories (lower, moderate, higher cognition) and occurrence of mild cognitive impairment (MCI)
- Follow-up
- 6 years
Methodological detailslongitudinal, group-based trajectory modeling, logistic regression
- Longitudinal
- Group-based trajectory modeling
- Logistic regression
Main finding
As reported in the abstract
Lower cognition trajectory
Each group vs ND/NAOOdds ratio (95% CI)
D/NAO
1.51(1.01–2.27)
D/AO
1.90(1.19–3.04)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Change from healthy to MCID/NAOvs ND/NAO | 1.52 (1.06–2.19) | |
| Change from healthy to MCID/AOvs ND/NAO | 1.61 (1.07–2.42) | |
| 0.512Odds ratio (log scale) |
Original publication
Dynapenic abdominal obesity is associated with long-term cognitive trajectories and mild cognitive impairment. Int J Obes (Lond). Published 1 November 2025. doi:10.
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