Integrated Assessment of Abdominal Adiposity and Muscle Strength for Atherosclerotic Cardiovascular Disease Risk in UK Biobank: A Comprehensive Analysis From Population Cohort to Multi‐Omics Molecular Exploration
Authors' conclusion
Higher WC and lower GS were independently and jointly associated with incident ASCVD. Their combination identified the highest-risk group and showed modest additive interaction.
Study context
- Population
- UK Biobank participants27,189 developed ASCVD
- Participants
- 271,061 participants
- Exposure
- High waist circumference (WC) and/or low grip strength vs reference categories
- Outcome
- Incident ASCVD
- Follow-up
- Median 14.8 years
Methodological detailspopulation-based, multi-omics exploratory mediation analysis
- Population-based
- Multi-omics exploratory mediation analysis
Main finding
As reported in the abstract
Each group vs referenceHazard ratio (95% CI)
High WC
1.35(1.31–1.39)
Low GS
1.14(1.11–1.17)
High WC and low GShighest risk
1.53(1.46–1.61)
Observational data: associations, not effects.
Further findings
Additive interaction of WC and grip strength (GS)
- RERI
- 0.11 (95% CI 0.03-0.19)
- Attributable proportion (AP)
- 7.04% (95% CI 1.67%-12.41%)
- Synergy index (SI)
- 1.26 (95% CI 1.01-1.50)
Sensitivity analyses
- Results were consistent across sensitivity analyses
Exploratory mediation analyses
- Shared metabolite and protein mediators; inflammatory, immune, metabolic and vascular remodelling pathways implicated
- Exploratory
Original publication
Integrated Assessment of Abdominal Adiposity and Muscle Strength for Atherosclerotic Cardiovascular Disease Risk in UK Biobank: A Comprehensive Analysis From Population Cohort to Multi‐Omics Molecular Exploration. Diabetes Obes Metab. Published 25 August 2026. doi:10.
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