Cardiac Autonomic Markers Partly Account for Adiposity‐Related Liver Enzyme Variation in Non‐Diabetic Adults With Overweight or Obesity
Authors' conclusion
Higher resting heart rate and lower HRV partly accounted for cross-sectional associations between adiposity and liver enzyme levels.
Study context
- Population
- Non-diabetic adults with overweight or obesity (clinical discovery cohort); supportive analyses in 21,383 UK Biobank participantsclinical discovery cohort
- Participants
- 432 adults
- Outcome
- Proportion of the associations between adiposity (BMI, WHtR) and liver enzymes (ALT, AST, gamma-glutamyl transferase (GGT)) accounted for by cardiac autonomic markers (resting mean heart rate, HRV)
Methodological detailsmediation analysis, multivariable regression, supportive UK Biobank analysis
- Mediation analysis
- Multivariable regression
- Supportive UK Biobank analysis
Main finding
As reported in the abstract
Resting mean heart rate (most consistent mediator): proportion of body mass index (BMI)–liver enzyme associations
16.6%-27.5%
Resting mean heart rate: proportion of waist-to-height ratio (WHtR)–liver enzyme associations
17.8%-36.9%
Heart rate variability (HRV) indices: proportion of BMI–liver enzyme associations
10.1%-28.2%
HRV indices: proportion of WHtR–liver enzyme associations
8.8%-29.9%
Observational data: associations, not effects.
Further findings
Mediation with homeostatic model assessment of insulin resistance (HOMA-IR) as parallel mediator
- Indirect effects through cardiac autonomic markers remained statistically significant, particularly for ALT
UK Biobank: resting pulse rate mediation of adiposity–liver enzyme associations
- Proportion accounted for by resting pulse rate
- 5.83%-9.47%
- n = 21 383
Original publication
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