Dynapenic obesity associated with incidence and progression trajectory of cardiometabolic diseases: a prospective cohort study
Authors' conclusion
This study indicated that there are differential effects associated with dynapenic obesity during the longitudinal progression of CMD. CRP and AIP may play a partial role in mediating this association.
Study context
- Population
- UK Biobank participants; dynapenic obesity assessed by handgrip strength, body mass index (BMI) and waist circumference
- Participants
- 446,862 participants
- Exposure
- Dynapenic obesity categories vs non-dynapenia and non-obesity
- Outcome
- CMD progression: first CMD (T2D, coronary heart disease, stroke), cardiometabolic multimorbidity (≥2 CMDs) and death
- Follow-up
- median 13.67-years follow-up
Methodological detailsmulti-state model, counterfactual mediation analysis
- Multi-state model
- Counterfactual mediation analysis
Main finding
As reported in the abstract
First CMD, CMM and death (multi-state model) · median 13.67 years
D/GO vs ND/NGOHazard ratio (95% CI)
First CMD
2.75(2.61,2.90)
CMM
4.61(4.05,5.24)
Death
1.68(1.56,1.80)
- Developed cardiometabolic diseases (CMD)
- 54,555
- Developed cardiometabolic multimorbidity (CMM)
- 5842
- Died
- 32,930
Observational data: associations, not effects.
Further findings
Proportion of D/GO–first CMD association mediated (vs ND/NGO)
- Mediated by C-reactive protein (CRP)
- 19.58% (95% CI: 18.66%, 20.18%)
- Mediated by atherogenic index of plasma (AIP)
- 18.99% (95% CI: 18.12%, 19.62%)
Proportion of D/AO–first CMD association mediated
- Mediated by CRP (higher than D/GO)
- 30.38%
- Mediated by AIP (higher than D/GO)
- 31.40%
Mediation of dynapenic obesity–CMM association
- CRP and AIP accounted for a greater proportion of the association with CMM than with first CMD
Original publication
Dynapenic obesity associated with incidence and progression trajectory of cardiometabolic diseases: a prospective cohort study. Int J Obes (Lond). Published 3 July 2025. doi:10.
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