Obesity

The influence of physical activity intensity on bone mineral density and trabecular bone score in young adults with overweight and obesity

Int J Obes (Lond)Published Cross-sectional analysis of data from a weight loss randomised clinical trial

Authors' conclusion

The study confirms the beneficial effects of light activity and MVPA on femoral neck and total hip BMD, challenging the traditional perception that higher body weight positively impacts bone health by revealing a negative correlation between BMI and TBS. Grip strength's consistent association with better bone health outcomes underlines the critical role of muscular strength.

Study context

Population
Young adults (aged 18–35 years) with overweight and obesity participating in a weight loss randomized clinical trial
Participants
638 adults
Methodological detailsmultiple linear regression
  • Multiple linear regression

Primary result

As reported in the abstract

Femoral neck BMD: associations (multiple linear regression)
Age, β
−0.0056, p < 0.001
Body mass index (BMI), β
0.0140, p < 0.001
Grip strength, β
0.2865, p < 0.001
Light physical activity, β
0.0002, p < 0.01
Moderate-to-vigorous physical activity (MVPA), β
0.0006, p < 0.01

Further findings

Total hip bone mineral density (BMD)

Total hip BMD showed similar associations

Spine BMD and mean Trabecular Bone Score (TBS)

Positive impacts of BMI and grip strength on spine BMD and mean TBS; light physical activity also benefited TBS

Original publication

The influence of physical activity intensity on bone mineral density and trabecular bone score in young adults with overweight and obesity. Int J Obes (Lond). Published 3 July 2025. doi:10.1038/s41366-025-01833-2

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