The influence of physical activity intensity on bone mineral density and trabecular bone score in young adults with overweight and obesity
Authors' conclusion
The study confirms the beneficial effects of light activity and MVPA on femoral neck and total hip BMD, challenging the traditional perception that higher body weight positively impacts bone health by revealing a negative correlation between BMI and TBS. Grip strength's consistent association with better bone health outcomes underlines the critical role of muscular strength.
Study context
- Population
- Young adults (aged 18–35 years) with overweight and obesity participating in a weight loss randomized clinical trial
- Participants
- 638 adults
Methodological detailsmultiple linear regression
- Multiple linear regression
Primary result
As reported in the abstract
Femoral neck BMD: associations (multiple linear regression)
- Age, β
- −0.0056, p < 0.001
- Body mass index (BMI), β
- 0.0140, p < 0.001
- Grip strength, β
- 0.2865, p < 0.001
- Light physical activity, β
- 0.0002, p < 0.01
- Moderate-to-vigorous physical activity (MVPA), β
- 0.0006, p < 0.01
Further findings
Total hip bone mineral density (BMD)
- Total hip BMD showed similar associations
Spine BMD and mean Trabecular Bone Score (TBS)
- Positive impacts of BMI and grip strength on spine BMD and mean TBS; light physical activity also benefited TBS
Original publication
The influence of physical activity intensity on bone mineral density and trabecular bone score in young adults with overweight and obesity. Int J Obes (Lond). Published 3 July 2025. doi:10. 1038/ s41366-025-01833-2
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