Regular collagen peptide administration exerts anti-obesity effects in high-caloric diet-fed rodents—a systematic review with meta-analysis of animal trials
Authors' conclusion
CP administration in rodents with obesity for at least 3 weeks demonstrated significant anti-obesity effects by positively influencing body mass, food intake, glucose metabolism, lipid markers, adipose tissue and adipokines. However, CP's anti-obesity effects in humans remain largely unexplored, necessitating further research.
Study context
- Population
- Genetically unmodified rodents fed a high-fat or high-caloric diet; preclinical controlled trials and RCTsnineteen studies in meta-analysis
- Participants
- 339 participants
- Comparison
- Collagen peptides vs placebo
- Outcome
- Obesity-related parameters (pooled SMD, random-effects)
- Follow-up
- ≥3 weeks
Methodological detailsrandom-effects model, PRISMA, SYRCLE risk of bias
- Random-effects model
- PRISMA
- SYRCLE risk of bias
Pooled result
As reported in the abstract
- Body mass
- SMD −1.87; P < 0.01
- Food intake
- SMD −1.43; P = 0.01
- Glucose metabolism
- SMD −2.21; P < 0.02
- Adipose tissue & organ content
- SMD −1.26; P < 0.01
- LDL
- SMD −2.02; P < 0.01
- Triacylglycerol
- SMD −2.16; P < 0.01
- Leptin
- SMD −1.33; P = 0.01
- Significant increase in HDL
- SMD = 1.14 (p = 0.04)
- Significant increase in adiponectin
- SMD = 1.04 (p < 0.01)
Original publication
Regular collagen peptide administration exerts anti-obesity effects in high-caloric diet-fed rodents—a systematic review with meta-analysis of animal trials. Int J Obes (Lond). Published 30 October 2025. doi:10.
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