Dynamic Screening of Thyroid Function for the Timely Diagnosis of Congenital Hypothyroidism in Very Preterm Infants: A Prospective Multicenter Cohort Study
Authors' conclusion
The incidence of CH and dTSH both increase with lower GA in VPIs. Dynamic screening of thyroid function by weeks within the first month of life is crucial for the timely diagnosis and treatment of CH in VPIs
Study context
- Population
- Very preterm infants (VPIs) born with gestational age (GA) <32 weeks admitted to participating institutes, January 1, 2019 to December 31, 2022
- Participants
- 5,992 infants
- Outcome
- Characteristics of thyroid function on weekly screening for timely diagnosis of CH
- Follow-up
- First month of life
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
Incidence of CH
Diagnosed with congenital hypothyroidism (CH), 456 VPIs
7.6%
95% CI 6.9–8.3%
CH incidence at GA 31 w
4.8%
CI 3.4–6.1%
CH incidence at GA <26 w
16.9%
CI 8.3–25.4%
Observational data: associations, not effects.
Further findings
Delayed TSH elevation (dTSH) among CH: identified after first screening
- dTSH among CH subjects
- 57.7% (CI 53.1-62.2%)
- dTSH at GA 31 w
- 38.1% (CI 27.5-48.7%)
- dTSH at GA <26 w
- 82.6% (CI 65.8-99.4%)
- Proportion of dTSH increased with decreasing GA
Cumulative rate of CH diagnosis by weekly screening · first month of life
- Diagnosed at first screening
- 42.3% (CI 37.8-46.9%)
- Cumulative by second week
- 76.1% (CI 72.2-80.0%)
- Cumulative by third week
- 90.6% (CI 87.9-93.3%)
- Cumulative by fourth week
- 98.9% (CI 97.9-99.9%)
Original publication
Dynamic Screening of Thyroid Function for the Timely Diagnosis of Congenital Hypothyroidism in Very Preterm Infants: A Prospective Multicenter Cohort Study. Thyroid. Published 11 August 2023. doi:10.
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