Lipids & metabolic liver disease
Dual-trajectory of Triglyceride-glucose (TyG) levels and lifestyle scores and their associations with ischemic stroke in a non-diabetic population: a cohort study
Authors' conclusion
This study reveals the significant associations between the identified TyG and lifestyle trajectories and the stratification of ischemic stroke risk among non-diabetics. The TyG index is a valuable indicator for assessing insulin resistance. However, the potential benefits of lifestyle changes for those with significantly high TyG levels need to be clarified by more research to develop more effective stroke prevention strategies.
Study context
- Population
- Non-diabetic participants of the Kailuan Study, three consecutive biennial surveys 2006–20115 trajectory subtypes
- Participants
- 44,403 participants
- Exposure
- TyG–lifestyle dual-trajectory subtypes vs group 3
- Outcome
- Ischemic stroke
Methodological detailsdual-trajectory model, multivariable-adjusted Cox regression
- Dual-trajectory model
- Multivariable-adjusted Cox regression
Main finding
As reported in the abstract
Ischemic stroke risk
Each group vs group 3Hazard ratio (95% CI)
Group 5greatest risk
1.81(1.51–2.18)
Group 4described as lowest risk
1.19(1.04–1.37)
Observational data: associations, not effects.
Original publication
Dual-trajectory of TyG levels and lifestyle scores and their associations with ischemic stroke in a non-diabetic population: a cohort study. Cardiovasc Diabetol. Published 28 June 2024. doi:10.
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