Lipids & metabolic liver disease
Is systemic inflammation a missing link between cardiometabolic index with mortality? Evidence from a large population-based study
Authors' conclusion
Elevated CMI is positively associated with all-cause mortality in the older adults. The association appeared to be partially mediated through inflammatory pathways, indicating that CMI may serve as a valuable indicator for poor prognosis among the older population.
Study context
- Population
- Adults aged over 65 years, six National Health and Nutrition Examination Survey (NHANES) cycles 2005–2016; mean age 73.28±5.50 years
- Participants
- 3,029 adults
- Exposure
- Association of cardiometabolic index with mortality
- Outcome
- All-cause mortality and cardiovascular mortality
- Follow-up
- Average 89.20 months
Methodological detailsNHANES 2005–2016, mediation analysis
- NHANES 2005–2016
- Mediation analysis
Main finding
As reported in the abstract
All-cause mortality per CMI
HR for all-cause mortality with cardiometabolic index (CMI) (multivariable-adjusted)
HR=1.11, 95% CI=1.01-1.21
All-cause deaths
1,015
Cardiovascular deaths
348
Observational data: associations, not effects.
Further findings
Mediation of CMI–all-cause mortality association by inflammation
- Proportion mediated by leukocytes
- 6.6%
- Proportion mediated by neutrophils
- 13.9%
Mean CMI · baseline
- Mean CMI
- 0.74±0.66
Original publication
Is systemic inflammation a missing link between cardiometabolic index with mortality? Evidence from a large population-based study. Cardiovasc Diabetol. Published 20 June 2024. doi:10.
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