Lipids & metabolic liver disease
Association of polycyclic aromatic hydrocarbons with systemic inflammation and metabolic syndrome and its components
Authors' conclusion
PAH exposure is associated with a higher prevalence of MetS or MetS components among adults and adolescents. Systemic inflammation partly mediated the association among adults.
Study context
- Population
- Adults and adolescents, National Health and Nutrition Examination Survey (NHANES 2001–2016)6,532 adults · 1237 adolescents
- Exposure
- Urinary polycyclic aromatic hydrocarbon (PAH) metabolite levels and metabolic syndrome (MetS)
- Outcome
- MetS and its components
Methodological detailsNHANES 2001-2016
- NHANES 2001-2016
Main finding
As reported in the abstract
MetS in adults, OR per one-unit increase in log-transformed urinary PAH metabolite level
- 1-OHNa, OR
- 1.11 (1.03-1.20) (95% CI)
- 2-OHNa, OR
- 1.18 (1.07-1.29) (95% CI)
- 3-OHFlu, OR
- 1.10 (1.01-1.12) (95% CI)
- 2-OHFlu, OR
- 1.18 (1.07-1.30) (95% CI)
- 1-OHPh, OR
- 1.17 (1.03-1.33) (95% CI)
- 1-OHP, OR
- 1.09 (1.01-1.22) (95% CI)
- 2&3-OHPh, OR
- 1.24 (1.09-1.40) (95% CI)
- ∑OH-PAHs, OR
- 1.17 (1.06-1.29) (95% CI)
Observational data: associations, not effects.
Further findings
MetS in adolescents, OR per one-unit increase in log-transformed urinary PAH metabolite level
- 2-OHNa, OR
- 1.61 (1.21-2.14) (95% CI)
- 2-OHFlu, OR
- 1.27 (1.01-1.60) (95% CI)
- 1-OHPh, OR
- 1.53 (1.15-2.03) (95% CI)
- ∑OH-PAHs, OR
- 1.61 (1.20-2.15) (95% CI)
Mediation by C-reactive protein (adults)
- CRP positively associated with urinary PAH metabolites and with MetS; proportion of PAH–MetS association mediated by CRP among adults
- 10.23% to 20.21%
Original publication
Association of polycyclic aromatic hydrocarbons with systemic inflammation and metabolic syndrome and its components. Obesity (Silver Spring). Published 4 April 2023. doi:10.
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