Lipids & metabolic liver disease
Central Sensitivity to Free Triiodothyronine With MAFLD and Its Progression to Liver Fibrosis in Euthyroid Adults
Authors' conclusion
Impaired central sensitivity to FT3 was associated with MAFLD and its progression to liver fibrosis. More prospective and mechanism studies are warranted to confirm these conclusions.
Study context
- Population
- Chinese euthyroid adults; liver steatosis and fibrosis diagnosed by vibration-controlled transient elastography
- Participants
- 7,906 euthyroid adults
- Exposure
- Q4 vs Q1 of thyroid hormone sensitivity indices
- Outcome
- Prevalence of MAFLD and of liver fibrosis
Methodological detailscommunity-based
- Community-based
Main finding
As reported in the abstract
Prevalence of MAFLD
Q4 vs Q1Odds ratio (95% CI)P value
FT3/FT4 ratio
1.62(1.38–1.91)
P < 0.05TFQIFT3
1.40(1.18–1.65)
P < 0.05Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Prevalence of liver fibrosis in participants with MAFLD, TFQIFT3TFQIFT3 | 1.45 (1.03–2.06) | P < 0.05 | |
| 0.512Odds ratio (log scale) |
Original publication
Central Sensitivity to Free Triiodothyronine With MAFLD and Its Progression to Liver Fibrosis in Euthyroid Adults. J Clin Endocrinol Metab. Published 31 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →