Lipids & metabolic liver disease
Changes in high-density lipoprotein cholesterol with risk of Cardiovascular Disease among initially high-density lipoprotein-high participants
Main finding · Incident CVDResult — go to the resultAdjusted hazard ratio 1.15 95% CI 1.05–1.25Authors' conclusion
In people with already high HDL-C levels, additional increases in HDL-C levels may be associated with an increased risk of CVD. This finding held true irrespective of the change in their LDL-C levels. Increasing HDL-C levels may lead to unintentionally elevated risk of CVD.
Study context
- Population
- Individuals with high baseline high-density lipoprotein cholesterol's (HDL-C) (≥ 60 mg/dL), Korea National Health Insurance Service-Health Screening Cohort; followed until 31 December 2019, cardiovascular disease (CVD) or death
- Participants
- 77,134 individuals517,515 person-years
- Exposure
- Greatest increase vs lowest increase in HDL-C levels
- Outcome
- Incident CVD
Methodological detailspopulation-based, Cox proportional hazards regression
- Population-based
- Cox proportional hazards regression
Main finding
As reported in the abstract
Adjusted hazard ratio
1.15
95% CI 1.05–1.25
Greatest HDL-C increasevs Lowest HDL-C increase
aHR 1.15 (95% CI 1.05–1.25)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | |
|---|---|---|
| CHD | 1.27 (1.11–1.46) | |
| CHD among participants with decreased LDL-C | 1.26 (1.03–1.53) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Changes in high-density lipoprotein cholesterol with risk of Cardiovascular Disease among initially high-density lipoprotein-high participants. Cardiovasc Diabetol. Published 28 March 2023. doi:10.
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