Lipids & metabolic liver disease
Acid accumulation is associated with metabolic alterations; higher energy, fat, and protein intake; and energy expenditure
Authors' conclusion
In healthy individuals, acid accumulation was associated with an unfavorable metabolic phenotype; higher 24-h EE; and increased total energy, fat, and protein intake. Acid accumulation markers, as putative markers of higher dietary acid load (e.g., from protein), may affect energy balance physiology promoting weight gain.
Study context
- Population
- Healthy adults with eGFR > 60 mL/min/1.73 m²
- Participants
- 286 adults
- Outcome
- Correlations of acid accumulation markers (CAG) with intake and 24-h EE
Main finding
As reported in the abstract
CAG vs total energy intake, partial r (p = 0.02)
0.17
CAG vs fat intake, partial r (p = 0.02)
0.17
CAG vs protein intake, partial r (p = 0.006)
0.20
CAG vs 24-h energy expenditure (EE), partial r (p = 0.0007)
0.24
Observational data: associations, not effects.
Further findings
Mediation analysis of CAG and total energy intake
- 24-h EE as partial mediator
- 40%
- Association remained significant, β (p < 0.0001)
- 0.15
Original publication
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