Lipids & metabolic liver disease
Elevated triglyceride-glucose index and its combination with anthropometric indices as indicators of the risk of new-onset transient ischemic attack: a prospective cohort study
Authors' conclusion
Elevated levels of TyG and combined anthropometric indices are associated with an increased risk of incident TIA. TyG-WHtR and TyG-WC showed a higher accuracy than the TyG index alone as indicators of TIA risk. This study demonstrates the importance of maintaining optimal TyG and anthropometric-related index levels for TIA prevention.
Study context
- Population
- Healthy populations, UK Biobank
- Participants
- 361,336 participants
- Exposure
- Highest vs lowest quartile of triglyceride-glucose (TyG) and combined anthropometric indices
- Outcome
- Incident TIA
- Follow-up
- Median 13.7 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
Incident TIA, Q4 vs Q1 by index
Each group vs Q1Estimate (95% CI)
Q4
HR (TyG) 1.22(1.12–1.33)
Q4
HR (TyG-WC) 1.29(1.17–1.42)
Q4
HR (TyG-BMI) 1.21(1.11–1.33)
Q4
HR (TyG-WHtR) 1.29(1.18–1.42)
Q4
HR (VAI) 1.35(1.24–1.47)
Q4
HR (LAP) 1.29(1.18–1.42)
- TyG, TyG-WC, TyG-BMI, TyG-WHtR, visceral adiposity index (VAI) and lipid accumulation product (LAP) significantly associated with increased transient ischemic attack (TIA) risk
- all P < 0.001
Observational data: associations, not effects.
Further findings
Population attributable fraction (PAF): TIA incidence reduction by maintaining Q1 levels
- TyG
- 9.07%
- TyG-WC
- 14.56%
- TyG-BMI
- 11.48%
- TyG-WHtR
- 15.75%
- VAI
- 17.18%
- LAP
- 15.83%
Restricted cubic splines (RCS) dose-response
- Linear associations with TyG, TyG-WC and TyG-BMI; nonlinear with TyG-WHtR, VAI and LAP
- P for nonlinear < 0.05
ROC: diagnostic accuracy for TIA
- TyG-WHtR AUC
- 0.678 (95% CI 0.676-0.679)
- TyG-WC AUC
- 0.673 (95% CI 0.672-0.675)
- Highest diagnostic accuracy
Subgroup effect modifiers
- Age
- P < 0.001
- Diabetes
- P = 0.021
Original publication
Elevated triglyceride-glucose index and its combination with anthropometric indices as indicators of the risk of new-onset transient ischemic attack: a prospective cohort study. Cardiovasc Diabetol. Published 4 November 2025. doi:10.
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