Dose-dependent Association of Alcohol Consumption With Obesity and Type 2 Diabetes: Mendelian Randomization Analyses
An erratum to this article was published (J Clin Endocrinol Metab, 13 Aug 2024 ↗)
Authors' conclusion
As opposed to observational associations, MR results suggest there may not be protective effects of modest alcohol consumption on obesity traits and type 2 diabetes. Heavy alcohol consumption could lead to increased measures of obesity as well as increased risk of type 2 diabetes.
Study context
- Population
- Participants of European ancestry in the UK Biobank
- Participants
- 408,540 participants
- Comparison
- Genetically predicted alcohol intake frequency
- Outcome
- Obesity (fat mass, obesity) and T2D
Methodological detailsUK Biobank, stratified by alcohol intake frequency, multiple sensitivity analyses, Results withstood multiple sensitivity analyses assessing validity of mendelian randomization (MR) assumptions
- UK Biobank
- Stratified by alcohol intake frequency
- Multiple sensitivity analyses
- Results withstood multiple sensitivity analyses assessing validity of MR assumptions
Main finding
As reported in the abstract
Fat mass, obesity and T2D per 1-drink-per-week increase in genetically predicted alcohol intake frequency, in individuals having >14 drinks/week
Fat mass increase (SD = 0.03 kg)
0.36 kg
Odds of obesity, 1.08-fold
1.08
95% CI 1.06–1.10
Odds of T2D, 1.10-fold
1.10
95% CI 1.06–1.13
Further findings
Sex differences
- Associations stronger in women than in men
Individuals having ≤7 drinks/week
- No evidence of association between genetically increased alcohol intake frequency and improved health outcomes; MR estimates largely overlapped with the null
Original publication
Dose-dependent Association of Alcohol Consumption With Obesity and Type 2 Diabetes: Mendelian Randomization Analyses. J Clin Endocrinol Metab. Published 27 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →