BMI, insulin sensitivity, and cognition in early type 2 diabetes: The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study
Authors' conclusion
In this study, higher BMI and lower insulin sensitivity in type 2 diabetes were cross-sectionally associated with better cognitive performance. However, only higher BMI was related to cognitive performance when both BMI and insulin sensitivity were considered simultaneously. The causality and mechanisms for this association need to be determined in future studies.
Study context
- Population
- Participants with T2D in the GRADE study; age 56.7 ± 10.0 years, 36.4% female5,018 completed cognitive assessments
- Participants
- 5,047 participants
- Outcome
- Association of BMI and insulin sensitivity (Matsuda index) with cognitive performance
- Follow-up
- Baseline
Methodological detailsbaseline assessment of the GRADE study
- Baseline assessment of the GRADE study
Main finding
As reported in the abstract
- Higher BMI and lower insulin sensitivity were related to better performance on memory and verbal fluency tests
- In models including BMI and insulin sensitivity simultaneously, only higher BMI was related to better cognitive performance
Observational data: associations, not effects.
Original publication
BMI, insulin sensitivity, and cognition in early type 2 diabetes: The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study. Obesity (Silver Spring). Published 27 June 2023. doi:10.
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