Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study
Main finding · Cardiovascular biomarkers, events and mortality by BMI and diabetesResult — go to the resultAdjusted incidence rate ratio 1.22 95% CI 0.96–1.56Authors' conclusion
Obesity and diabetes are additively associated with adverse cardiovascular biomarkers and mortality risk. While adiposity metrics are more strongly correlated with cardiovascular biomarkers than diabetes-oriented metrics, both correlate weakly, suggesting that other factors underpin the high cardiovascular risk of normal-weight diabetes.
Study context
- Population
- UK Biobank participants stratified by BMI and diabetes status
- Participants
- 451,355 participants5,323,190 person-years
- Exposure
- BMI categories (normal, overweight, obese) by diabetes status; normal-weight nondiabetes as comparator
- Outcome
- Cardiovascular biomarkers (CIMT, arterial stiffness, LVEF, CCI) and incident MI, ischemic stroke and cardiovascular death
Methodological detailsstratified by ethnicity-specific BMI categories and diabetes status, Poisson regression, adjusted incidence rate ratios (IRRs)
- Stratified by ethnicity-specific BMI categories and diabetes status
- Poisson regression, adjusted IRRs
Main finding
As reported in the abstract
Cardiovascular biomarkers, events and mortality by BMI and diabetes
Adjusted incidence rate ratio
1.22
95% CI 0.96–1.56
P = 0.1
Normal weight, diabetesvs Obese, no diabetes
adjusted IRR 1.22 (95% CI 0.96–1.56); P = 0.1
- Without diabetes, overweight/obesity associated with higher carotid intima-media thickness (CIMT), arterial stiffness and cardiac contractility index (CCI) and lower left ventricular ejection fraction (LVEF); relationships diminished with diabetes
- P < 0.005
- Within BMI classes, diabetes associated with adverse cardiovascular biomarker phenotype, particularly normal weight
- P < 0.005
- Incident MI, ischemic stroke and cardiovascular mortality rose across increasing BMI categories without diabetes
- P < 0.005
- Comparable pattern in diabetes groups
- P for interaction > 0.05
Observational data: associations, not effects.
Further findings
Diabetes prevalence and BMI distribution
- Participants with diabetes
- 5%
- With diabetes: normal weight, overweight, obese
- 10%, 34%, 55%
- Without diabetes: normal weight, overweight, obese
- 34%, 43%, 23%
Original publication
Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study. Diabetes Care. Published 27 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →