Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study
Authors' conclusion
Our MR study provides robust evidence supporting the association between genetically predicted increased insulin concentrations and decreased concentrations of Lp(a). These findings suggest that hyperinsulinaemia, which typically accompanies T2D, can partially explain the inverse relationship between low Lp(a) concentrations and an increased risk of T2D.
Study context
- Population
- European-ancestry populations: fasting insulin GWAS meta-analyses; Lp(a) GWAS in UK Biobankfasting insulin GWAS meta-analyses 151,013 · Lp(a) GWAS in UK Biobank 361,194
- Comparison
- Genetically predicted fasting insulin levels and Lp levels
- Outcome
- Association between genetically predicted fasting insulin levels and Lp(a) levels (IVW)
Methodological detailstwo-sample summary-level Mendelian randomization (MR), inverse-variance weighted method, sensitivity analyses: MR-Egger, weighted median, MR pleiotropy residual sum and outlier (MR-PRESSO), leave-one-out, MR Steiger
- Two-sample summary-level MR
- Inverse-variance weighted method
- Sensitivity analyses: MR-Egger, weighted median, MR-PRESSO, leave-one-out, MR Steiger
Main finding
As reported in the abstract
Lp(a) levels per genetically predicted fasting insulin (IVW)
β (inverse-variance weighted (IVW)), SE = 0.05, P = 0.003
- 0.15
Further findings
Sensitivity analysis: weighted median (WME)
- β (WME), SE = 0.07, P = 0.0002
- - 0.26
- Supported a causal relationship
Sensitivity analysis: MR-Egger
- β (MR-Egger), SE = 0.13, P = 0.11
- - 0.22
- Did not support a causal relationship
Original publication
Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study. Cardiovasc Diabetol. Published 29 August 2024. doi:10.
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